For example, cyclic RGD (Arg-Gly-Asp) peptide ligand decorated polyplex micelle loading pDNA encoding the human soluble form of vascular endothelial growth factor receptor-1 (or soluble fms-like tyrosine kinase-1) mediated αvβ3 and αvβ5 integrin-mediated uptake and showed anti-tumor activity against subcutaneously xenograftedBxPC3 human pancreatic adenocarcinoma in mice [126]. The gene discussed is FLT1; the disease is neoplasm.