SOD1 and amyotrophic lateral sclerosis: Moreover, since deregulated expression of SOD1 was exclusively found in SALS2 but not in SALS1 patients [16,38], and the sporadic ALS-Glia human subset shares some transcriptional signatures with murine SOD1-G93A spinal microglia [15,53], SOD1-G93A NSC-34 may represent a suitable preclinical model to investigate a distinct subset of ALS human pathology.