PRKCE and amyotrophic lateral sclerosis: Given the decreased PKCε expression and its impaired phosphorylation state in ALS, we investigated the long-term biological effect of Bryostatin-1, a macrolide lactone and potent agonist of PKCε [32] in both WT and G93A NSC-34 motor neuron-like cells [37], triggered to death by two different apoptotic ways (growth factor starvation and chemokines-induced toxicity).