Here, we observed that PKCε mRNA expression level does not show differences when ALS is considered as a single entity, while it displays a significant downregulation in particular molecular subtypes of sporadic ALS patients obtained by bulk transcriptomic-based profiling (SALS2 from Aronica et al. [16] and ALS-Glia subset from Tam et al. [15]). This evidence concerns the gene PRKCE and amyotrophic lateral sclerosis.