When CCN2-EGFP TG mice were placed on a CDAA-HF diet for 3 weeks (by which time fibrosis is beginning to be initiated [44]), staining for hepatic CCN2 (EGFP) and αSMA significantly increased (Figure 2B), consistent with their WT counterparts (see Figure 1H–K). This evidence concerns the gene ACTA1 and hydrops fetalis.