The biological importance of CCN2 is shown by hepatocyte overexpression of CCN2 in transgenic mice, which caused exacerbation of the fibrotic response to chemical toxins [36] and by the use of siRNA or hammerhead ribozyme to down-regulate CCN2 expression which reduced HSC activation and liver fibrosis in rodent models and highlighted CCN2 as a potential therapeutic target [37,38,39,40,41]. Here, CCN2 is linked to Hepatic fibrosis.