CCN2 and diabetes mellitus: In a C57BL6/J mouse model of NASH resulting from a 20-week high-fat diet (HFD) and streptozotocin-induced diabetes mellitus (DM) over the last 5 weeks, hepatic CCN2 mRNA concentrations did not show statistically significant differences compared to chow-fed animals, but nonetheless, they trended upward and were correlated with increased collagen and TIMP-1 expression [65].