In chronic human liver disease and rodent experimental fibrosis models, CCN2 is often produced by activated HSC in which it promotes activation, proliferation, chemotaxis, adhesion, integrin expression, fibrogenesis, and matrigenesis [24,25,26,27,28,29,30,31,32], although hepatocytes, cholangiocytes, vascular smooth muscle cells, and portal fibroblasts may produce CCN2 as well [21,32,33,34,35]. Here, CCN2 is linked to fibrosis.