Alms1 mutant (foz/foz) C57BL6/J mice fed a high-fat diet for 24 weeks led to diet-induced NASH that included hepatocyte ballooning, inflammation, high NAFLD activity, and ALT levels, as well as severe hepatic fibrosis and increased hepatic expression of PDGF-α, αSMA, collagen-1α, and CCN2, the latter of which was associated with CD-147 expression around hepatocytes and increased MMP activity and expression of MMP-2 and -9 [66]. This evidence concerns the gene CCN2 and metabolic dysfunction-associated steatohepatitis.