However, the total CCN2 transcript level (assessed using primers that detect both native mouse CCN2 mRNA and transgenic human CCN2 mRNA) was dramatically elevated in either mouse strain, but the total CCN2 mRNA in Alb-CCN2 TG mouse liver was much higher than that in WT mouse liver on either control or CDAA-HF diet (Supplementary Figure S3C). This evidence concerns the gene CCN2 and hydrops fetalis.