Specifically, amelanotic and non-dendritic melanocytes/melanoblasts are difficult to detect, given the lack of specific markers, whereas the fully differentiated melanocytes of the bulb region (M-FMU) have been identified in HFs by their expression of melanocytic markers such as MITF, tyrosinase and tyrosinase-related proteins 1 and 2 (TRP1 and DCT/TRP2, respectively) [2,6]. Here, TYR is linked to Hand-foot syndrome.