Exploration of the SNP-gene pairs identified from the eQTL-DE analyses (Supplemental Tables S1 and S2) found several SNPs that were located within several known risk factor genes for AD, including CR1, PICALM, MEF2C, CASS4, SLC24A4/RIN3, INPP5D [12], CLNK, CNTNAP2, ABI3, PLCG2 [13,15], BLNK, JAZF1, ABCA1, TMEM106B [14]. The gene discussed is RIN3; the disease is Alzheimer disease.