Immunohistochemical evaluation of SIRT7 expression in malignant and adjacent normal tissues of the prostate gland in 57 patients with PC (sample included all pathological stages, mean age was 68 years, GS ≥ 6) revealed SIRT7 overexpression in tumors and a positive correlation with malignancy grade [89]. The gene discussed is SIRT7; the disease is pachyonychia congenita.