However, the list of driver genes remained almost the same, including PRAD, AR, TP53, MYC, ZMYM3, PTEN, PTPRD, ZFP36L2, ADAM15, MARCOD2, BRIP1, APC, KMT2C, CCAR2, NKX3-1, C8orf58, and RYBP, albeit with AR gene mutations as a result of PC treatment [26]. The gene discussed is PTEN; the disease is pachyonychia congenita.