Based on the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis results, the characteristic genes of the HMI cluster were found to participate in various classical tumor signaling pathways and immunological processes, including PI3K-Akt, NF-kappa B, and IL-17 signaling pathways (Figure 5H, Supplementary Table S8). The gene discussed is AKT1; the disease is neoplasm.