In this study, we examined whether p190RhoGEF over-expression in macrophages affects the atherosclerotic disease process in a mouse model: p190RhoGEF-TG mice were cross-bred with atherosclerosis-prone ApoE−/− mice to obtain p190RhoGEF-TG mice with an ApoE−/− background (TG/ApoE−/−). Here, APOE is linked to atherosclerosis.