As a result, perinatal hypothyroidism suppresses TH-responsive genes in the Purkinje cell, such as the retinoic acid receptor-related orphan receptor (ROR)alpha, inositol 1, 4, 5-triphosphate receptor type 1 (IP3R1), and sarco/endoplasmic reticulum Ca2+-ATPase 2 (SERCA2), resulting in aberrant Purkinje cell development [28]. Here, ITPR1 is linked to hypothyroidism.