The increased expression of miR-375-3p in estrogen-receptor-positive breast tumors has been associated with a higher tumor proliferative profile, based on the action of this miR on the target gene RAS, dexamethasone-induced 1 (RASD1), which encodes a member of the small GTPase superfamily induced by dexamethasone [30]. The gene discussed is ESR1; the disease is breast neoplasm.