Interestingly, four microRNA (miRNAs), i.e., miR-155-5p, miR-146a-5p, miR-323a-5p, and mir-1307-3p, were upregulated upon TNF-α stimulation in the exosomes derived from FLSs, and different studies have shown the role of these miRNAs in the pathogenesis of RA [111]. The gene discussed is TNF; the disease is rheumatoid arthritis.