NFKB1 and cardiac hypertrophy: NF-κB (nuclear factor kappa light chain enhancer of activated B cells) is a long-known TF to regulate myocardial hypertrophy, cardio-protection, chronic inflammatory response, myocardial apoptosis, post-translational modifications, and its numerous interacting coactivators and corepressors, including histone acetyltransferases (HATs) and histone deacetylases (HDACs) [22].