VWF and endothelial dysfunction: The increased levels of factors such as vWF and Factor VIII due to endothelial dysfunction and chronic inflammation are counterbalanced by the reduction in anticoagulant factors due to decreased synthesis of prothrombin, factor V and X, and anticoagulant factors (protein C, protein S, and antithrombin), as is expected due to reduced liver function [117,118,119,120,121].