Other mechanisms influence vWF levels, such as endotoxemia and gut dysbiosis: endotoxemia causes vWF release from endothelial cells and the upregulation of FVIII; moreover, an increased activation of tissue factor emerged in this condition with the consequent stimulation of Factor VII that leads to the activation of the coagulation cascade [110]. This evidence concerns the gene VWF and serum lipopolysaccharide activity.