FD is a rare X-linked lysosomal storage disorder (LSD) which results in a decreased activity of lysosomal alpha-galactosidase-A (α-Gal A) enzyme causing the accumulation of glycosphingolipids, mostly globotriaosylceramide (Gb3), globotriaosylsphingosine (lyso-Gb3), as well as galabiosylceramide (Ga2) and their isoforms/analogs in the vascular endothelium, nerves, cardiomyocytes, renal glomerular podocytes and biological fluids [61]. The gene discussed is ETFA; the disease is Fabry disease.