Matrine can inhibit the TLR4/MyD88/NF-κB pathway, NLRP3 inflammatory body activation, and the secretion of proinflammatory cytokines [84] and can regulate the JNK signaling pathway to inhibit the activation of NLRP2 inflammatory bodies, thereby effectively alleviating the symptoms of CLP-induced sepsis in mice [85]. This evidence concerns the gene TLR4 and Sepsis.