JAK2 and acute kidney injury: Curcumin has also been reported to inhibit NF-κB and janus kinase2 (JAK2)/signal transducer and activator of Transcription 3 (STAT3) signaling and the expression of p-JAK2/STAT3, p-p65, and BCL2-Associated X (BAX) in mice with acute kidney injury to alleviate septic acute kidney injury effectively in CLP mouse models [26].