This suggests the factors impacting AT1 receptor signaling in pregnancy, such as the presence or absence of AT2 receptors [43], metabolic derangements [44], or AT1 autoantibody-binding, might facilitate the negative cellular effects of Ang II (the promotion of inflammation [45] or renal complications [46]), which lead to the progression of hypertension. This evidence concerns the gene AGTR2 and hypertensive disorder.