As previous studies of pregnancy have indicated that classical biomarkers, such as activation of the RAAS, PRA (or direct renin concentrations), and plasma aldosterone concentrations (PAC), are reduced in gestational hypertension or pre-eclampsia [25,27,37], we examined the concentrations of PRA-S and aldosterone generated using RAS Fingerprint in our cohort of NT and HYP pregnancies (Figure 1). The gene discussed is REN; the disease is X-linked dominant hypophosphatemic rickets.