Because TSLP is mainly an epithelium-derived alarmin, with a critical upstream role in the initiation of different immune responses [69], in transgenic mice with TSLP overexpression specifically in the lung or skin, the inflammatory response is accompanied by an increase in IgE and type 2 cytokine levels, which contributes to asthmatic or atopic dermatitis-like manifestations [109,110]. The gene discussed is TSLP; the disease is atopic eczema.