Subsequently, TSLP-activated DCs also stimulate naive CD4+ T cells to differentiate into T follicular helper cells (defined by expression of IL-21, CXCR5, CXCL13 and BCL6), which can induce IgG and IgE secretion by memory B cells, linking TSLP to IgE production in allergy [50]. Here, IGHE is linked to Allergy.