The histamine H4 receptor regulates TH2-cytokine profile through TSLP in nasal allergy and the ubiquitin-specific peptidase 25 (USP25) downregulation involved in inflammation and the immune responses enhances the TSLP signalling in the nasal epithelium via decreased expression of TNF receptor-associated factor 3 (TRAF3), thereby exacerbating inflammation in allergic rhinitis [80]. The gene discussed is USP25; the disease is allergic rhinitis.