In addition, the simultaneous modulating effects of E169 on the level of disturbance in the expression of PI3K, Akt, and GSK-3β proteins were assessed in the hippocampus of treated mice with MK801-induced amnesia, to clarify whether H3R antagonism has a simultaneous role in the Akt-mTOR signaling pathway in the hippocampal tissues of treated animals. The gene discussed is HRH3; the disease is amnesia.