Finally, we found a positive regulation of genes related to immune response to virus infections (Type I Interferons, inflammatory cytokines (IL-6, TNF and NF-κB), NLRP3 inflammasome, anti-inflammatory cytokines (IL-10), and cell death pathways (pyroptosis and apoptosis)) in RA individuals. The gene discussed is NFKB1; the disease is viral infectious disease.