These include mutations in the TWIK-related spinal cord potassium channel (TRESK) gene, which alters gene function, which in turn can affect nociceptive processing, and familial advanced sleep phase disorder (FASPS), caused by mutations in casein kinase 1δ (CK1δ), leading to disrupted circadian rhythms and migraine with aura [28,29]. This evidence concerns the gene KCNK18 and migraine with aura.