Moreover, fatty acids (FAs) are downregulated in TNBC relative to other BC subtypes, but, intriguingly, two key enzymes involved in de novo fatty acid synthesis, FASN and acetyl-CoA carboxylase 1 (ACACA), were both found to be upregulated at the protein level in tumors with high quantities of phospholipids containing de-novo-generated fatty acids. Here, ACACA is linked to breast cancer.