Moreover, we also observed an increased amount of VEGFR2 in the brain during the 4th week of the cuprizone model, which could be associated with BBB disruption, since VEGFR2 is the main signal transducer in endothelial cells [39] and its level indicates the vascular permeability in different models [40], such as brain injury and brain tumors [41]. This evidence concerns the gene KDR and brain neoplasm.