PTK2 and esophageal squamous cell carcinoma: In the course of their investigations, Zhang et al. [163] were able to show that glucose-induced growth-factor-independent ESCC cell proliferation required the phosphorylation of FAK at histidine residue 58 (FAKpoH58,glucose-induced) and that this phosphorylation was mediated by the activity of nucleoside diphosphate kinase 1 (NME1).