PTK2 and triple-negative breast carcinoma: Regarding FAK’s effects on the TME, FAK, for instance, regulates VEGFR2 and VEGF expression and, therefore, supports angiogenesis in triple-negative breast cancer (TNBC) and TNBC-derived MDA-MB-231 and MDA-MB-468 cell lines, as demonstrated by the HUVEC tube formation assay in vitro [155].