F2R and gastric cancer: Using the human gastric cancer cell lines MKN 45 (which normally does not express PAR1) and MKN74, it could be demonstrated that the expression of protease-activated receptor-1 (PAR1/F2RL1) [144] in MKN45-PAR1-transfected cells or constitutively PAR1-expressing MKN74 cells leads to the inactivation of the HIPPO signaling pathway and thus to the accumulation and activation of YAP.