YAP1 and cancer: Through YAP depletion experiments, the authors could further demonstrate that the glucose-metabolism-related pentose phosphate pathway (PPP), known to promote cancer, is causally triggered through YAP overexpression, since YAP in conjunction with TEAD4 stimulated the gene expression of 6-phosphogluconolactonase (PGLS), one of the decisive enzymes within the PPP.