Accumulating evidence indicates that FAK acts as an essential central hub that finely regulates multiple cellular processes, such as cell cycle progression and proliferation, growth, spread and migration, survival, angiogenesis, epithelial-to-mesenchymal transition (EMT), cancer stemness, and the establishment of an immunosuppressive TME (tumor microenvironment) [52,53]. This evidence concerns the gene PTK2 and cancer.