LMNA and neoplasm: This is an extremely important point, as there is initial evidence from recent studies that, for example, a senescent (SASP phenotype) tumor stroma, i.e., TME, can also influence the cytoskeletal tension and lamin A/C (LMNA)-mediated nuclear integrity of malignant tumor cells in such a way that they decrease and the tumor cells thus receive increased mechanical compliance [197].