For instance, the photosensitizer verteporfin, used in age-related macular degeneration [164,165], could be shown to, among other things, reduce the YAP protein level and prevent nuclear translocation through the upregulation of the 14-3-3 protein, with the latter responsible for YAP binding and cytoplasmic retention, followed by proteasomal degradation [8,166]. Here, YAP1 is linked to age-related macular degeneration.