To test the effect of cyclic CNGRC on the anti-tumour activity of hPK5, mouse models of LLC and human colorectal adenocarcinoma (Colo 205) were treated with hPK5/NGR-hPK5 and hPK5/NGR-hPK5 with cisplatin. The gene discussed is RTN4R; the disease is colorectal adenocarcinoma.