The methylation levels of the 15 genes MAST1, PRDM14, ZNF177, DNM2, SSH1, AP2M1, CACNA1E, CPEB4, DLGAP2, CCDC181, GCM2, ITPRIPL1, POM121L2, KCNQ1, and TIMP3 were studied by modified MS–HRM in small malignant breast tumor (test set, n = 48), fibroadenoma (n = 24), and healthy tissue from patients with fibroadenoma (n = 24). The gene discussed is CPEB4; the disease is breast cancer.