Hepcidin also ameliorates liver fibrosis by inhibiting hepatic stellate cells (HSCs)’ activation, which facilitates liver fibrosis via the degradation of ferroportin in HSCs, increasing Akt phosphorylation and finally prohibiting TGFb1-inducible Smad3 phosphorylation [72]. Here, TGFB1 is linked to Hepatic fibrosis.