Therefore, the use of stable UFO Env trimers generated from consensus sequences that can better represent the viral populations at the early time points (weeks 4, 22, 30, 53 and 78) for sequential immunization to better mimic the natural infection history may have allowed the elicitation of broader and more potent neutralization activities than the repeated immunization of the BG505 Env trimer. Here, ERVW-1 is linked to infection.