Furthermore, the administration of CAY10444, an S1PR3 antagonist, reduces BBB injury via the downregulation of the C-C motif chemokine ligand 2—C-C motif chemokine receptor 2 (CCL2-CCR2) axis, p-p38 mitogen-activated protein kinase (MAPK), and intercellular adhesion molecule 1 (ICAM1), and the upregulation of ZO-1 following acute intracerebral hemorrhage in in vivo and in vitro rat models [206]. This evidence concerns the gene CCL2 and intracerebral hemorrhage.