Inherited cancer syndromes with known germline mutations, such as the Lynch syndrome (MLH1, MLH2, MLH6, PMS2), familiar breast and ovarian cancer (BRCA1 and BRCA2), familial adenomatous polyposis (FAP), familial atypical multiple mole melanoma (CDKN2A), and Peutz–Jeghers (STK11/LKB1), show an increased risk of PDAC [8]. The gene discussed is STK11; the disease is Lynch syndrome.