This pre-angiogenic or “avascular” stage restricts growth and dissemination, reaffirming the angiogenesis importance [94] since when angiogenesis occurs, rapid tumor growth occurs, leading to poorly irrigated regions with a consequent hypoxic and acidic milieu [95], a fact having a profound impact by the VEGF release stimulated by a lower pH and, thus, enhancing angiogenesis [96]. This evidence concerns the gene VEGFA and neoplasm.