CD274 and neoplasm: These include TMB in cell-free DNA from the plasma of NSCLC patients treated with atezolizumab as subsequent-line treatment [124], or with pembrolizumab-based first-line treatment [125], soluble PD-1/PD-L1 [126], PD-L1 mRNA and exoPD-L1 [127], or PD-L1-positive circulating tumor cells [128].