Since 2013, several randomized trials have shown the superiority of programmed cell death protein (PD)-1/PD-ligand (L)1 immune checkpoint inhibitors (ICIs) in terms of overall survival (OS), in both the first- and second-line treatments of metastatic non-small-cell lung cancer (NSCLC); in addition, several anti-PD1-PD-L1 drugs have become integrant or exclusive components of the treatment strategy for unresectable or metastatic advanced NSCLC [1,2,3,4]. Here, CD274 is linked to non-small cell lung carcinoma.