While the frontal cortex of people with Alzheimer’s disease or Down syndrome has decreased Tuberin levels [104], other studies have found a significant upregulation of phospho-Tuberin (Thr1462) in the post-mortem frontal cortex of people with AD and PD/DLB, which is mediated by the Akt-PTEN pathway [105]. Here, PTEN is linked to early-onset autosomal dominant Alzheimer disease.