Many of the overexpressed proteins in symptomatic carriers are linked to cell proliferation, migration, and cell cycle progression via Notch1, β-Catenin, NF-kB, AKT, and ERK1 signaling, and pathways closely related to AD, including PRPF4B, S100A16, PRPS2, PIK3C2B, MAPRE1, and SVEP1. This evidence concerns the gene MAPRE1 and Alzheimer disease.