MAPT and Alzheimer disease: AD is characterized by the formation of extracellular amyloid β (Aβ) aggregates derived from proteolytic cleavage of the Amyloid Precursor Protein (APP), known as amyloid plaques, and by the intraneural neurofibrillary tangles (NFTs) of hyperphosphorylated tau in the entorhinal cortex, hippocampus (Hp), limbic system, and temporal cortex, principally [3].