RTRAF and early-onset autosomal dominant Alzheimer disease: Interestingly, neurological illnesses such as autism, neurodevelopmental disorders, deafness dystonia syndrome, microcephaly, Alzheimer’s disease, and several cancer types have been associated with RTRAF, DIP2C, YARS, CNBP, BIN3, DYNLRB1, and TIMM13. In addition, DIP2 paralogues and spastic hemiplegia are connected [57].