Also, Guanylate Cyclase 2C or Heat Stable Enterotoxin Receptor (GUCY2C or GC-C), the most upregulated protein in the symptomatic carrier, inhibits phosphodiesterase 3 (PDE3), inducing cell cycle arrest, cytostasis, and senescence via activation of p21, PKGII, and p38 MAPK [94], inhibits proliferation by decreasing AKT signaling and β-catenin and promotes cell differentiation and migration in Colorectal Carcinoma Cells [95,96]. Here, GUCY2C is linked to colorectal carcinoma.