Using GeneAnalytics, we obtained similar results for muscular dystrophy, ALS, FAD, with 32 proteins matched (3 DE in brain, PI4KA, S100A4, and DES; 4 in blood, DNAH6, CEP152, CRMP1, ITGA11; and 25 GeneCards inferred as ADAM10, ALB, HSPA1A, HSPA5, MAPK1, NOS2, SOD1, and STAT1), HD, and surprisingly hereditary spastic paraplegia with 24 matched genes, ALDH18A1 as a causative mutation; 13 differentially expressed in skeletal muscle as BAG2, CANX, SCARB2, and UBR5; and 12 inferred genes (ALDH18A1, CANX, DCTN1, FUS, ITPR1, KIF5B, KIF5C, MATR3, REEP5, SETX, SOD1, and VPS13D). The gene discussed is S100A4; the disease is hereditary spastic paraplegia.