The hallmarks enriched for our exosome proteomes (IPMN vs. CT and PDAC-S vs. CT) support the main biological pathways and functions discussed earlier, particularly the complement system and related DEPs, such as C3, C4BPB, CFB, CFH, CLU, KLKB1, SERPINA1, and SERPING1. Here, KLKB1 is linked to pancreatic intraductal papillary-mucinous neoplasm.