In IPMN samples, the most notable alterations observed in the proteomics profile compared to healthy controls were the over-expression of KLKB1, LBP, SERPINA1, and CFB, and the downregulation of C3, C5, APOD, and C1QA. This evidence concerns the gene KLKB1 and pancreatic intraductal papillary-mucinous neoplasm.