MCU and Alzheimer disease: We also found interaction between sex and genotype [F (1,28) = 14.18; p < 0.001] in the mRNA levels of the mitochondria channel calcium Mcu, with an overall decrease in Mcu mRNA levels in hippocampal astrocytes from 3×Tg-AD female offspring (Tukey’s multiple comparisons test; */#p < 0.05; Figure 6B).