DAGLB and Alzheimer disease: Regarding the enzymatic machinery for endocannabinoid biosynthesis and degradation, an interaction between sex and genotype was found on Daglb mRNA levels [F (1,28) = 6.881; p < 0.05], with an overall decrease in Daglb mRNA levels in 3×Tg-AD female astrocytes compared to 3×Tg-AD male group (Tukey’s multiple comparisons test; * p < 0.05; Figure 3B).