PTGS2 and Alzheimer disease: To analyze whether hippocampal astrocytes from 3×Tg-AD mice present greater inflammatory reactivity or astrogliosis, we analyzed gene expression of inflammatory markers and markers indicative of glial reactivity: glial fibrillary acidic protein (Gfap), vimentin, tumor necrosis factor α (Tnfα), interleukins (Il1b and Il6), and prostaglandin-endoperoxide synthase 2 (Ptgs or Cox2).