MAPK3 and non-small cell lung carcinoma: Recently, another in vivo study using both ectopic and orthotopic lung tumour mouse models confirmed the efficacy of this treatment in non-small cell lung cancer (NSCLC) cells and showed that curcumin potentiates the anticancer effect of cisplatin, which is associated with the down-regulation of the expression of COX-2, p-ERK1/2 and EGFR [67].