Interestingly, in the haplotype analysis of two TS loci (Table 3), the 3R-G (TSER/TS 1170), T-G (TS 1100/TS 1170), C-0bp (TS 1100/TS 1494), and G-0bp (TS 1170/TS 1494) haplotypes showed a significant association with CAD risk. The gene discussed is TYMS; the disease is coronary artery disorder.