In the analysis of three TS loci (Table 3), the 3R-C-0bp (TSER/TS 1100/TS 1494) and C-A-0bp (TS 1100/TS 1170/TS 1494) haplotypes were associated with CAD occurrence (OR = 16.522, 95% CI = 5.110–53.414, p < 0.0001; OR = 20.462, 95% CI = 4.918–85.133, p < 0.0001), while the 3R-T-G, 2R-T-A (TSER/TS 1100/TS 1170), and T-G-0bp (TS 1100/TS 1170/TS 1494) haplotypes were significantly associated with a reduced risk of CAD. This evidence concerns the gene TYMS and coronary artery disorder.