TYMS and diabetes mellitus: Table S7 presents the baseline characteristics of CAD patients and control subjects in both sample groups. The CAD patients showed higher frequencies of MetS (p < 0.0001, sample 1; p < 0.0001, sample 2), DM (p < 0.0001, sample 1; p = 0.020, sample 2), and hypertension (p = 0.048, sample 1; p = 0.178, sample 2) compared to the controls (Table S7). Additionally, the genotype frequencies of the TS polymorphisms were significantly different between the control and CAD groups in sample 1 (Table S8).