We also demonstrated that MPT0G236 inhibited the activity of Class I HDACs (HDAC1, HDAC2, HDAC3, and HDAC8), as well as of a Class IIb HDAC, HDAC6, leading to the increased acetylation of α-tubulin and histone H3 in both colorectal cancer cells. The gene discussed is HDAC8; the disease is colorectal cancer.