Because S-proteins are shed by infected cells in vivo and most COVID-19 vaccines encode SARS-CoV-2 S-proteins, increases in markers of inflammation, coagulopathy, and NETosis following exposure of neutrophils and lung endothelial cells to S-proteins could explain some vascular complications observed in COVID-19 patients [73] and post-COVID-19 vaccination adverse events. Here, PROS1 is linked to blood coagulation disease.