As LUNAR1 binds to enhancer elements in the promoter of IGF1R, its own promoter, and the N1ICD, it was suggested that it exploits the chromatin configuration to recruit the mediator complex and sustain the full activation of the IGF1R promoter, fuelling T-ALL development (Figure 1(IIIc)) [103]. The gene discussed is IGF1R; the disease is acute lymphoblastic leukemia.