LncRNAs may also modulate Notch1 signalling indirectly by binding proteins related to NOTCH1, such as the Paired box gene 8 (PAX8) protein which was proposed to activate the N1ICD in the nucleus by modulating its phosphorylation status and affecting the transcription of its target genes, as well as promoting aerobic glycolysis in pancreatic carcinoma. Here, NOTCH1 is linked to exocrine pancreatic carcinoma.