For example, NOTCH1 expression is regulated, at the transcriptional level, by neighbouring genes, such as lncRNA RP11-611D20.2 (also known as LINC01573) which acts as a cis transcriptional activator of NOTCH1 signalling in paediatric T cell acute lymphoblastic leukaemia (T-ALL) and is therefore named NALT1 (NOTCH1-associated lncRNA in T-ALL) (Figure 1(I)) [78]. Here, NALT1 is linked to acute lymphoblastic leukemia.