Several years later, the genome-wide mapping of NOTCH1-regulated transcripts in T-ALL revealed 182 lncRNAs, among which 55% were interacting with the N1ICD–RBPJΚ (recombination signal binding protein for immunoglobulin Kappa J region, also known as CSL) activator complex. Here, NOTCH1 is linked to acute lymphoblastic leukemia.