NOTCH1 mRNA is tightly controlled by miRNAs binding to its 3′ UTR region; however, lncRNAs can efficiently prevent such interactions as described for FEZF1-AS1 in non-small-cell lung cancer (NSCLC) [83] and SNHG7 in breast cancer [84], acting as miR-34a sponges sequestering this miRNA from its target mRNAs, consequently increasing the amount of NOTCH1 mRNA. This evidence concerns the gene FEZF1 and non-small cell lung carcinoma.