A slightly different mode of NOTCH1 regulation via lncRNAs has been reported in head and neck squamous cell carcinoma (HNSCC) patients, whose low expression of lncRNA ZFAS1 (ZNFX1 antisense RNA 1) correlated with the upregulation of NOTCH1 and better survival, suggesting an oncogenic role of this lncRNA. This evidence concerns the gene NOTCH1 and head and neck squamous cell carcinoma.