Different studies have demonstrated how the primary toxic role of asbestos exposure at the level of the mesothelium is crucial, where a consequent inflammatory status, due to cytokines released in response to fibers, was associated with the production of ROS, which in turn promotes an oxidative stress status and stimulates, mainly through the redox-sensitive transcription factor NF-kB, cell survival and the development of a tumor microenvironment [4]. This evidence concerns the gene NFKB1 and neoplasm.