S1PR1 and cancer: Other proteins that have been found over expressed in TCC microglia in chronic migraine mice include the glucagon-like peptide-1 receptor (GLP-1R) [94], which was previously found to inhibit neuropathic and cancer pain, and the sphingosine-1-phosphate receptor 1 (S1PR1) [95], whose blocking was known to relieve the development of chronic pain and to inhibit the activation of microglia.