FBN1 and systemic sclerosis: Three subclusters, in particular, were more frequently distributed in SSc patients than in healthy controls, showing upregulation of genes involved in immune response (CXCL9/10/11- and INF-pathway, HLA expression), mesenchymal transition and wound healing (SFRP2, PRSS23, SFRP4, ADAM12, ACTA2, MFAP5, and FBN1), cell motility, proliferation, and apoptosis (CXADR, GATA3).