They compared the daily expression of amyloid β scavengers in 6- and 12-month APP/PS1 (Alzheimer’s disease mice model) and wild-type mice.Transthyretin showed a rhythmic expression in wild-type 12-month-old female mice. The angiotensin-converting enzyme was rhythmic in the choroid plexus of 6-month-old wild-type female mice. The gene discussed is APP; the disease is early-onset autosomal dominant Alzheimer disease.