The discovery of several genes, including C9ORF72, TARDBP, SQSTM-1, FUS, VCP, CHCHD10, and TBK-1, associated with the ALS/FTD continuum, and the consequent detection of new disease mechanisms, including those related to inflammatory/autoimmune responses, is allowing the development of new potential therapeutic strategies applicable to the entire cohort of patients. Here, TARDBP is linked to amyotrophic lateral sclerosis.