The decrease in NR1D1 was associated with de-phosphorylation of the mitochondrial fission protein DRP1, increased reactive oxygen species (ROS), reduced mitochondrial fission, mitochondrial DNA release, and activation of cyclic GMP-AMP synthesis (cGAS) inflammatory signaling, HSC activation, and hepatic fibrosis [49]. This evidence concerns the gene NR1D1 and Hepatic fibrosis.