CD4 and psoriasis: Specifically, apart from the MHC system, the genes found to be related with psoriasis belong to the pathways of skin barrier, innate immune system with particular relevance of nuclear factor-kappa B (NF-kB) and interferon (IFN) signaling, and the adaptative immune system, with an implication of CD8+ and CD4+ T cells, especially Th17 [10].