Genetic variants related to generalized pustular psoriasis susceptibility include IL36RN, resulting in DITRA (Deficiency of The Interleukin-36-Receptor Antagonist) a monogenic autoinflammatory disorder [54] linked with a more severe manifestation of the disease and earlier onset age [21], and CARD 14 (caspase recruitment domain family member 14, which is primarily expressed in keratinocytes and activates NF-kB signaling. The gene discussed is CARD14; the disease is generalized pustular psoriasis.