Patient 1 presented the germline LP variant CYP1B1 c.1159G > A (Table 2), along with 49 VUS, including two missense variants NTRK1 c.16C > T and NFATC2 gene c.1952G > A reported as cancer-associated (COSMIC, https://cancer.sanger.ac.uk/cosmic (accessed on 30 May 2023)). The gene discussed is NTRK1; the disease is cancer.