According to the available research findings, miR-34a-5p suppresses tumor growth by targeting IL6R, MMP9, MMP14, AXL, and SATB2 genes, which are upregulated in the typical case of miR-34a suppression in OSCC, therefore overactivating several oncogenic signaling pathways including the IL6/STAT3 and AKT/GSK-3β/β-catenin/Snail cascades [99,100,101]. Here, STAT3 is linked to neoplasm.