PIK3CA and neoplasm: MiR-124-3p exerts tumor-suppressive effects by targeting several oncogenes, such as ITGB1, TRIM14, and CCL2, which are overexpressed under miR-124 downregulation, subsequently stimulating oncogenic pathways that include the PI3K/AKT cascade, intense growth factor signaling, or the downregulation of PTEN tumor suppressor in the case of TRIM14 upregulation.