BRCA2 and pancreatic neoplasm: Regarding non-modifiable factors, a ten-fold increase in the risk of PDAC has been estimated in individuals with a family history of pancreatic cancer (at least three first-, second-, third-degree), hereditary pancreatitis, Peutz-Jeghers syndrome, and familial atypical multiple mole melanoma, whereas a moderate increase (5–10-fold increase) has been found in individuals with BRCA2 mutations, chronic pancreatitis, cystic fibrosis, and a family history of pancreatic cancer in two first-degree relatives [6].