AKT1 and familial pancreatic carcinoma: In multiple malignancies such as pancreatic cancer, cytokines, chemokines, and growth factors activate the class I phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) (PI3K/AKT/mTOR) signaling pathway, which plays a fundamental role in motility regulation, metabolism, cell proliferation, cell migration, and cell survival [26].