APOE and dementia: Using automated algorithm, the statistical software automatically assigned and ranked each risk factors; the result is depicted in Figure 2A. APOE ε4/ε4 and ε3/ε4 are the main risk factor of a memory disorder, with 350% (ε4/ε4) and 47.3% (ε3/ε4) more participants within the subgroup having a dementia diagnosis.